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#3242 – Is Cancer Genetic or Metabolic Disease

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Tuesday 2/5/19

Source: CF Essentials
ByProfessor Thomas Seyfried

IS CANCER A GENETIC OR METABOLIC DISEASE? PART 1

THE CURRENT CANCER CRISIS

Over 1,600 people die each day from cancer in the U.S., according to recent data from the American Cancer Society (1). The 4.8 percent increase in death rate from cancer over the last five years is greater than the 4.2 percent increase in U.S. population growth over the same period.

In this context, it is important to take a close look at both the prevailing and alternative theories of cancer’s origin. Over the next several weeks, we will review the history of and evidence for the somatic mutation theory (SMT) and the mitochondrial metabolic theory (MMT) of cancer.

THE SOMATIC MUTATION THEORY PERSISTS AS THE DOMINANT EXPLANATION FOR THE ORIGIN OF CANCER

The prevailing view today is that cancer is a “genetic disease” involving nuclear mutations in oncogenes and tumor suppressor genes (2-4). A typical tumor is thought to contain several so-called “driver gene” mutations that regulate the tumorigenic phenotype (5,6). The nuclear genomic instability seen in nearly all types of tumor cells is considered the primary cause of the cancer’s hallmarks, which include sustained proliferative signaling, evasion of growth suppressors, resistance to cell death, replicative immortality, enhanced vascularization, and activation of invasion and metastasis (2). Somatic mutations, which arise randomly during DNA replication in normal non-cancerous stem cells, are considered the origin of cancer (7).

THE MITOCHONDRIAL METABOLIC THEORY OF CANCER

Although the SMT is currently the dominant theory for the origin of cancer, the mitochondrial metabolic theory is emerging as an alternative explanation. Mitochondria are the organelles that produce most cellular energy and are largely responsible for maintaining metabolic homeostasis of the body. The MMT originated with the work of Otto Warburg in the last century and has been resurrected more recently by the work of Seyfried and others (11-17).

Read on HERE


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